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杨中铎
2018-11-18 22:25  点击:[]

杨中铎(1976年9月-),生命科学与工程学院教授,硕士研究生导师。1998年本科毕业于兰州大学化学系基地班,2001年在兰州大学有机化学专业获理学硕士学位,2004年在中科院上海药物研究所有机化学专业获理学博士学位,2006年从中山大学、广州医药集团基础医学博士后出站。国家自然科学基金项目通讯评议人,Natural Product Research、Medicinal Chemistry Research、Fitoterapia、Journal of Separation Science等杂志审稿人。目前主要从事药物化学、药物合成教学、研究生指导以及天然药物的发现及结构改造研究等方面的工作,先后承担纵横向研究课题13项,主持国家自然科学基金项目3项,公开发表学术论文60余篇,其中第一或通讯作者发表SCI收录论文42篇,第一发明人申请国家发明专利14项,其中已授权发明专利9项,参编教材1部,2013年获得兰州理工大学杰出人才项目资助。在药学-专业硕士、生物工程-学术硕士、生物与医药等硕士授权点有招生资格。

主持的科技项目立项情况:

(1)主持完成国家自然科学基金项目“植物中天然乙酰胆碱酯酶抑制剂的高通量发现研究”(20802031);(18万)(青年基金)

(2)主持完成国家自然科学基金项目“天然单胺氧化酶抑制剂的快速识别及跟踪分离研究”(21262022);(50万)(地区基金)

(3)主持进行国家自然科学基金项目“踝节菌属真菌中具有PI3K抑制活性的新型Viridin类似物的高通量发现研究”(21762027);(38万)(地区基金)

(4)主持进行甘肃省科技支撑项目“抗阿尔兹海默症一类新药N -(4 -硝基 苯)氧乙基异锥丝明的药效学研究”(1604FKCA084);(10万)

(5)主持完成兰州市科技局项目“藏药止泻木生物碱衍生物抗老年痴呆药效学研究”(2014-1-151);(10万)

(6)主持完成兰州市生物医药专项“藏药甘蒙锦鸡儿降血糖中药五类新药研究”(2009-2-14); (10万)

(7)主持兰州理工大学优秀青年资助计划项目“甘肃药材中产乙酰胆碱酯酶抑制剂的内生菌的筛选及其次生代谢物研究”(Q200904);(12.5万)

(8)主持完成兰州理工大学博士启动基金项目“甘肃药用锦鸡儿属植物之抗乙酰胆碱酯酶活性成分研究”(SB08200605);(15万)

(9)主持完成浙江省自然科学基金“天然单胺氧化酶抑制剂的快速发现研究”(LY12B02005)(5万)

(10)主持兰州理工大学杰出人才项目(J201303)(20万)

2016-2019年发表的论文:

(1)Jun-Wen Zhao,Zhong-Duo Yang*(通讯作者), Shuan-Yan Zhou, Li-Jun Yang, Jian-Hui Sun, Xiao-Jun Yao, Zong-Mei Shu, Shuo Li. Wortmannine F and G, two new pyranones from Talaromyces wortmannii LGT-4, the endophytic fungus of Tripterygium wilfordii. Phytochemistry Letters, 2019, 29 : 115–118

(2)Xiao-Wei Chen,Zhong-Duo Yang*(通讯作者), Xiao-Fei Li, Jian-Hui Sun, Li-Jun Yang and Xin-Guo Zhang. Natural Product Research, 2019, 33:108–112.

(3)Jian-Hui Sun, Zhong-Duo Yang,**(通讯作者), et al.Chemistry of Natural Compounds, 2019. 55:775-778

(4)Zhong‑Duo Yang*(通讯作者), Zhi-Jie Li, et al. Current Microbiology, 2019,76:904–908

(5)Muammer Abdelwahed Elsunni1, Zhong-Duo Yang*(通讯作者). Secondary metabolites of the endophytic fungi penicillium polonicum and their monoamine oxidase inhibitory activity, Chemistry of Natural Compounds, 2018, 54(4):1018-1019.

(6)B.Y. Zhu,Z. D. Yang*(通讯作者),, X. R. Chen, J. Zhou, Y. H. Gao, C. J. Xian, K. M. Chen. Exposure Duration Is a Determinant of the Effect of Sinusoidal Electromagnetic Fields on Peak Bone Mass of Young Rats, Calcified Tissue International (2018) 103:95–106

(7)Xiayun Zhang,Zhongduo Yang*(通讯作者),Dengmin Xie, Donglei Liu, Zhenbin Chen , Ke Li, Zhizhong Li, Brandon Tichnell and Zhen Liu, Design and synthesis study of the thermo-sensitive poly (N-vinylpyrrolidone-bN, N-diethylacrylamide), Designed MonoMers and Polymers, 2018, 21 (1):43–54.

(8)Xiao-Wei Chen,Zhong-Duo Yang*(通讯作者), Jian-hui Sun, Tong-tong Song, Bao-ying Zhu, Jun-wen Zhao. Colletotrichine A, a new sesquiterpenoid from Colletotrichum gloeosporioides GT-7, a fungal endophyte of Uncaria rhynchophylla, Natural Product Research, 2018, 32(8): 880–884

(9)Jian-Li Dong,Zhong-Duo Yang*(通讯作者), Shuang-Yan Zhou, Hai-Tao Yu, Xiao-Jun Yao, Hong-Yan Xue, Zong-Mei Shu. Two Stemona alkaloids from Stemona sessilifolia (Miq.) Miq. Phytochemistry Letters, 2017, 19:259–262

(10)Jing-Yun Sun,Zhong-Duo Yang*(通讯作者), Guang-Chao Fu, Yong-Gang Wang, Hong-Yan Xue & Zong-Mei Shu. A new wortmannine derivative from a Tripterygium wilfordii endophytic fungus Talaromyces wortmannii LGT-4. Natural Product Research, 2017, 31(21): 2527–2530

(11)Xian-Dong Zhai,Zhong-Duo Yang*(通讯作者),Zhi Luo, Hong-Tao Xu. Asymmetric catalyzed intramolecular aza-Michael reaction mediated by quinine-derived primary amines. Chinese Chemical Letters, 2017, 28(8):1793–1797

(12)Bo WeiaZhong-Duo Yang(通讯作者), Dan-Feng Shi, Xiao-Jun Yao, Ming-Gang Wang. Inhibition of Monoamine Oxidase by Stilbenes from Rheum palmatum, Iranian Journal of Pharmaceutical Research, 2016, 15 (4): 885-892.

(13)Guang-Chao Fu,Zhong-Duo Yang*(通讯作者), Shuang-Yan Zhou, Xin-Ming Li, Hai-Tao Yu, Xiao-Jun Yao, Jian-Guo Fang Zong-Mei Shua, Hong-Yan Xue, Yong-Gang Wang. Wortmannines A–C, three novel wortmannin derivatives with an unusual five-membered B ring from the endophytic fungusTalaromyces wortmanniiLGT-4. Tetrahedron Letters, 2016, 57: 4608–4611.

(14)Bo Wei,Zhong-Duo Yang*(通讯作者), Xiao-wei Chen, Shuang-Yan Zhou, Hai-Tao Yu, Jing-Yun Sun,Xiao-Jun Yao, Yong-gang Wang, Hong-Yan Xue. Colletotrilactam A–D, novel lactams fromColletotrichum gloeosporioidesGT-7, a fungal endophyte ofUncaria rhynchophylla. Fitoterapia, 2016, 113: 158–163.

(15)Kang-Kang Zhi,Zhong-Duo Yang*(通讯作者), Shuang-Yan Zhou, Xiao-Jun Yao, Shuo Li, Fei Zhang. A new furanosteroid fromTalaromyces sp. lgt-4, a fungal endophyte isolated fromTripterygium wilfordii. Natural Product Research, 2016, 30 (19): 2137–2141.

(16)Guang-Chao Fu,Zhong-Duo Yang*(通讯作者), Shuang-Yan Zhou, Hai-Tao Yu, Fei Zhang, Xiao-Jun Yao. Two new compounds, deacetylisowortmins A and B, isolated from an endophytic Fungus,Talaromyces wortmanniiLGT-4. Natural Product Research, 2016, 30 (14): 1623–1627.

(17)Qiu-Hong Zhao,Zhong-Duo Yang*(通讯作者), Zong-Mei Shu, Yong-Gang Wang and Ming-Gang Wang. Secondary metabolites and biological activities ofTalaromyces sp. LGT-2, an endophytic fungus fromTripterygium Wilfordii.Iranian Journal of Pharmaceutical Research, 2016, 15 (3): 453-457.

(18)Kangkang Zhi,Zhong-Duo Yang*(通讯作者), Jie Sheng, Zongmei Shu, Yin Shi. A peroxidase-linked spectrophotometric assay for the detection of monoamine oxidase inhibitors. Iranian Journal of Pharmaceutical Research, 2016, 15 (1): 131-139.

第一发明人授权专利:

(1)杨中铎,智康康,王鸣刚,圆锥山蚂蝗枝叶中分离的化合物及其制备方法和用途 ,2016.06.25,中国,ZL201410159716.6

(2)杨中铎,赖东海,百部生物碱单体成分及其用途,2015.9.2,中国,ZL20121014 9954.X (3)杨中铎,赖东海,任晋,周静怡,一种抗糖尿病药物及制备方法,2014.4.2,中 国,ZL201110175246

(4)杨中铎,靳国斐,盛捷,舒宗美,张新国,止泻木生物碱衍生物及其用途,2014 .12.24,中国,ZL201310110844.7

(5)杨中铎,段东柱,李涛,杨明俊,任晋,止泻木总生物碱提取物的有效单体制备 方法及其用途,2013.2.13,中国,ZL201110074795.7

(6)杨中铎,李涛,马建忠,王鸣刚,一种治疗慢性胃炎的药物及其制备方法,2012 .6.6,中国,ZL 200810018018.9

(7)杨中铎,段东柱,杨明俊,任晋,张东博,钩藤生物碱单体的用途,2011.12.21,中国,ZL201010128383.2

(8)杨中铎,张旭,杨明俊,张东博,任晋,一种荷叶提取物及其单体成分和其用途 ,2011.3.30,中国,ZL200910117596.2

(9)杨中铎,黄裕,刘菊妍,杜松,李咏华,一种抗抑郁药物及制备方法,2009.10.中国,ZL 200610035942.9



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